The Ellis Island Medals of Honor are awarded to individuals who have made it their mission to share their knowledge, courage, compassion and talents while maintaining the traditions of their ethnic heritage. Since the award was first given in 1986, the medal has been recognized by Congress as one of the United States’s most prestigious awards. The award is presented during a ceremony on Ellis Island. Dr. Farokhzad currently serves as the director of the Laboratory of Nanomedicine and Biomaterials, where his research is focused on the development of therapeutic nanoparticle technology. The nanotechnologies that Farokhzad has helped pioneer have formed the basis for a new class of targeted nanoparticles for treatment of major human diseases like cancer and cardiovascular disease. Additionally, his research has also been used in the formation of a new class of nanoparticle vaccines and a class of integrative combination nanomedicines that help to treat cancers, inflammation and infectious diseases.
Atherosclerosis is a chronic inflammatory disease of the arteries and the leading cause of death worldwide. Therapeutics that can temper inflammation using the body’s innate mechanisms are powerful complementary strategies to existing treatments. Our research team in collaboration with Prof. Ira Tabas from Columbia University have developed a polymeric nanoparticle using a rapid microfluidic platform enabling the production of small and robust nanoparticles effectively entrapping IL10 protein (an anti-inflammatory cytokine), in a matter of minutes. The nanoparticles also have a targeting ligand for plaque retention and therefore the ability to release IL-10 in a spatiotemporal manner. These findings were recently published in ACS Nano.
The recent Worldview feature by Scientific American features a list of 100 Biotech leaders and recognizes leading researchers for their fundamental insights into biological processes, as well as those who develop these insights to create biology-based goods and services that are the essence of biotechnology. The honorees also include entrepreneurs and business experts who have been highly influential in enabling biotechnology to flourish, in addition to key media figures who have helped spread this message to the wider community. Dr. Farokhzad was named an honoree on this list for his work on developing and commercializing nanoparticle based drug delivery systems for the treatment of a range of diseases.
[Read more from Scientific American]
Nanometer-sized “drones” that deliver a special type of healing molecule to fat deposits in arteries could become a new way to prevent heart attacks caused by atherosclerosis, according to a study in pre-clinical models by the Omid Farokhzad’s lab at Brigham and Women’s Hospital (BWH) and Ira Tabas’s lab at Columbia University Medical Center. These findings were published in the February 18th online issue of Science Translational Medicine. Although current treatments have reduced the number of deaths from atherosclerosis-related disease, atherosclerosis remains a dangerous health problem: Atherosclerosis of the coronary arteries is the #1 killer of women and men in the U.S., resulting in one out of every four deaths. In the study, targeted biodegradable nano ‘drones’ that delivered a special type of drug that promotes healing (‘resolution’) successfully restructured atherosclerotic plaques in mice to make them more stable. This remodeling of the plaque environment would be predicted in humans to block plaque rupture and thrombosis and thereby prevent heart attacks and strokes. “This is the first example of a targeted nanoparticle technology that reduces atherosclerosis in an animal model,” said co-senior author Omid Farokhzad, MD, associate professor and director of the Laboratory of Nanomedicine and Biomaterials at BWH and Harvard Medical School (HMS). “Years of research and collaboration have culminated in our ability to use nanotechnology to resolve inflammation, remodel and stabilize plaques in a model of advanced atherosclerosis.” In this study, targeted nanomedicines made from polymeric building blocks that are utilized in numerous FDA approved products to date, were nanoengineered to carry an inflammation resolving drug payload in the form of a biomimetic peptide called Ac2-26. Furthermore, this peptide was derived from one of the body’s own natural inflammation-resolving proteins called Annexin A1. The way the nanomedicines were designed enabled this biological therapeutic to be released at the target site, the atherosclerotic plaque, in a controlled manner.
[Read more from bizjournals] [Read more from HMS] [Read more from The Telegraph]
A collaboration between Harvard Medical School researchers at Brigham and Women’s Hospital and Dana-Farber Cancer Institute has utilized nanomedicine technologies to develop a drug-delivery system that can precisely target and attack cancer cells in the bone, as well as increase bone strength and volume to prevent bone cancer progression. Bone is a favorable microenvironment for tumor growth and a frequent destination for metastatic cancer cells. Targeting cancers within the bone marrow remains a crucial oncologic challenge due to issues of drug availability and microenvironment-induced resistance. In this study, engineered bone-homing polymeric nanoparticles for spatiotemporally controlled delivery of therapeutics to bone were developed, which diminish off-target effects and increase local drug concentrations. These findings were published online in PNAS (June 30th, 2014 edition) and suggest that bone-targeted nanoparticle anti-cancer therapies offer a novel way to deliver a concentrated amount of drug in a controlled and target-specific manner to prevent tumor progression in multiple myeloma.
[Read more from HMS] [Read more from CRUK]