Principal Investigator

Omid Farokhzad, M.D.
Associate Professor
Brigham and Women's Hospital
Harvard Medical School
[read more]

Wall Street Journal Interview

Cellular Surgeons: New Era of Nanomedicine

New York Academy of Sciences Event

ecancertv: Polymeric Nanoparticles for Medical Applications

Our Research

     

Nanotechnology has generated a significant impact in nearly every aspect of science. Our research seeks novel nanomaterials and nanotechnologies in order to develop advanced drug delivery systems with the promise to improve health care. Highly interdisciplinary and translational, our research is focused on multifunctional, nanoparticle-based drug delivery systems. We seek to improve nanoparticle synthesis and formulation and its therapeutic efficacy. Additionally, we develop robust engineering processes to accelerate translation of nanoparticle-based drugs into the drug development pipeline. At the same time, we emphasize a fundamental understanding of the interface between nanomaterials and biological systems. Read our recent reviews below:

See below for some of our selected research articles. Click on images for more detail:

Transepithelial transport of fc-targeted nanoparticles by the neonatal fc receptor for oral delivery:

A study on the immunocompatibility properties of lipid-polymer hybrid nanoparticles with heterogeneous surface functional groups:

Engineering of targeted nanoparticles for cancer therapy using internalizing aptamers isolated by cell-uptake selection:

Synthesis of Size-Tunable Polymeric Nanoparticles Enabled by 3D Hydrodynamic Flow Focusing in Single-Layer Microchannels:

Effects of ligands with different water solubilities on self-assembly and properties of targeted nanoparticles:

Development of poly(ethylene glycol) with observable shedding:

Group News

Nanoparticles developed for myleoma and bone microenvironment targeting (07/08/14)[Read more...]
Welcome Dr. Harshal Zope to join our team! (06/15/14)
Welcome Dr Yanlan Liu, Dr. Xiaoding Xu and Dr. Arif Islam to join our team! (03/12/14)
Science Translational Medicine paper published on oral delivery of neonatal Fc receptor targeted nanomedicines for insulin delivery. (11/27/2013) [Read more...]
Dr. Farokhzad is awarded the PCF Movember Challenge Award for 2013! (11/01/2013) [Read more...]
Dr. Farokhzad is awarded the 2013 RUSNANOPRIZE! (11/01/2013) [Read more...]
Dr. Farokhzad and his research team are featured in the Harvard Gazette (10/11/2013) [Read more...]
Welcome Dr. Basit Yameen to join our team! (09/09/2013)
Dr. Farokhzad Named a 2013 Health Care Champion by the Boston Business Journal (08/16/2013) [Read more...]
Dr. Farokhzad Named One of Top Innovators in Massachusetts By the Boston Globe! (05/19/2013) [Read more...]
Congratulations to Dr. Archana Swami for her poster prize at the MIT Polymer Day Symposium! (05/02/2013)
Welcome Dr. Mikyung Yu, Dr. In-hyun Lee, Dr. Won IL Choi, Dr. Renata Leitão and Dr. Cristian Vilos to join our team! (05/02/2013)
PNAS article on Novel Nanomedicines Clear up Inflammation (03/26/2013) [Read more...]
Congratulations to Dr. Archana Swami for receiving an 'Outstanding Paper' award from the ASME at NEMB2013! (31/01/2013)
The Economist features BIND-014 in their Science and Technology section (11/21/2012) [Read more...]
Targeted Nanoparticle Tested in Patients with Cancer, reports the National Cancer Institute (04/17/2012) [Read more...]
Welcome Dr. Giuseppe Palmisano to join our team! (04/01/12)
Congratulations to Steffi Sunny for securing a PhD position on the Applied Science and Engineering PhD program at Harvard University! (04/01/12)
Congratulations to Shrey Sindhwani for securing a Physician Scientist Training Program (MD-PhD) position at the University of Toronto! (04/01/12)
Themed nanomedicine review published: "Targeted polymeric therapeutic nanoparticles: design, development and clinical translation" (03/05/2012) Article link
Dr Farokhzad is elected to the College of the Fellows of the American Institute of Medical and Biological Engineering (02/22/2012) [Read more...]
Targeted nanoparticles for cancer therapy with internalizing aptamers (01/03/2012) [Read more...]
Congratulations to Dr. Xiaoyang Xu on the award of his National Cancer Institute funded Ruth L. Kirschstein National Research Service Award Post-doctoral Fellowship! (01/03/2012)
Congratulations to Dr. Jinjun Shi on the award of his National Cancer Institute K99/R00 Career Award! (11/30/2011)
Selecta Biosciences initiates Phase 1 clinical study of SEL-068, a first-in-class synthetic nicotine vaccine for smoking cessation and relapse prevention (11/21/2011) [Read more...]
Congratulations to Dr. Jinjun Shi for his BWH Biomedical Research Institute award! (11/10/2011)
Welcome Dr. Nazila Kamaly to join our team! (01/25/2011)
BIND Biosciences initiates Phase 1 clinical study of BIND-014, a first-in-class targeted nanoparticle therapeutic for cancer therapy(01/07/2011) [Read more...]
Welcome Dr. Jun Wu, Dr. Xueqing Zhang and Changwei Ji to join our team! (11/15/2010)
Press Release - New nanoparticles could improve cancer treatment (10/05/2010) [Read more...]
Press Release - New nanoparticles target cardiovascular disease, article by Juliana Chan et. al (01/18/2010) [Read more...]
Welcome Dr. Suresh Gadde to join our team! (12/15/2009)
Welcome Dr. Xiaoyang Xu to join our team! (10/19/09)
Welcome Dr. Archana Mukherjee to join our team! (08/19/09)
[Group News Archive]

Selected Publications

Immunocompatibility properties of lipid-polymer hybrid nanoparticles with heterogeneous surface functional groups, Salvador-Morales C, Zhang L, Langer et al, Biomaterials, 30 (2009) 2231.
Engineering of targeted nanoparticles for cancer therapy using internalizing aptamers isolated by cell-uptake selection, Xiao Z, Levy-Nissenbaum E, Alexis F et al, ACS Nano, 6 (2012) 696.
Synthesis of size-tunable polymeric nanoparticles enabled by 3D hydrodynamic flow focusing in single-layer microchannels., Rhee M, Valencia M, Rodriguez MI et al, Advanced Materials, 23 (2011) H79.
Effects of ligands with different water solubilities on self-assembly and properties of targeted nanoparticles, Valencia PM, Hanewich-Hollatz MH, Gao W et al, Biomaterials, 23 (2011) 6226.
Poly (ethylene glycol) with Observabel Shedding, Valencia PM, Hanewich-Hollatz MH, Gao W et al, , 23 (2010) 6567.
Preclinical Development and Clinical Translation of a PSMA-Targeted Docetaxel Nanoparticle with a Differentiated Pharmacological Profile, Hrkach J, Von Hoff D, Ali MM et al, Science Translational Medicine, 4 (2012) 128ra39.
Targeted polymeric therapeutic nanoparticles: design, development and clinical translation, N Kamaly, Z Xiao, P Valencia et alChem. Soc. Rev, 41 (2012) 2971.
Precise engineering of targeted nanoparticles by using self-assembled biointegrated block copolymers, F. Gu, L. Zhang, B. A. Teply et alPNAS, 105 (2008) 2586.
Quantum dot-aptamer conjugates for synchronous cancer imaging, therapy, and sensing of drug delivery based on bi-fluorescence resonance energy transfer, V Bagalkot, L Zhang, E Levy-Nissenbaum et alNano Lett., 7 (2007) 3065.
Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo, O. Farokhzad, J. Cheng, B. A. Teply, et al PNAS, 103 (2006) 6315.
[Browse Publication List...]