Targeted Nanoparticle Tested in Patients with Cancer

Targeted Nanoparticle Tested in Patients with Cancer

Researchers from Brigham and Women’s Hospital, Harvard Medical School, Massachusetts Institute of Technology (MIT), BIND Biosciences, Inc., and colleagues published the development of a targeted polymeric nanoparticle, called BIND-014, in the April 4th issue of Science Translational Medicine. This work describes the first human trial to test a targeted nanoparticle capable of controlling a drug’s release. These nanoparticles have been optimized to release the chemotherapy drug docetaxel in a controlled manner, in order to deliver a higher and more sustained dose of the drug directly to tumors. This approach allows for up to 10 times more drug to reach tumors resulting in: (i) anti-tumor efficacy at relatively low administerd doses of the drug, (ii) anit-tumor efficacy in tumor types that the drug has shown minimal activity in, and (iii) a reduction in drug toxicity and off-target effects.
[Read more from the National Cancer Institute][Read more from the Science Magazine] [Read more from Brigham Women’s Hospital] [Read the press release from Boston Herald] [Read the press release from MIT] [Read a patient’s interview] [Read more on marketwatch] [Read more on ABC news]

About the Author

dh070 administrator

Comments Are Closed!!!